Our Research

The Yang Laboratory is dedicated to identifying novel therapeutic targets and engineering next-generation interventions for pediatric malignancies, particularly neuroblastoma. By bridging mechanism-driven basic discovery and rigorous preclinical evaluation, the lab accelerates the translation of research into safer, more precise and highly effective therapies for children with high-risk cancers.

Core Research Pillars

1. Target Discovery and Precision Therapeutics

We interrogate the unique molecular landscapes of pediatric tumors to uncover distinct biochemical vulnerabilities and develop tailored therapeutic modalities.

2. Translational Screening and Drug Repurposing

To expand immediately actionable clinical options for pediatric patients, we systematically evaluate the hidden therapeutic potential of existing, clinically validated compounds.

3. Advanced Preclinical Methodological Pipeline

Our laboratory operates a robust pipeline designed to validate therapeutic hypotheses from the benchtop through to advanced translational models.