Vasileva Laboratory
About the Lab
Our lab in the Center for Cancer and Immunology Research (CCIR), with the support of the Brain Tumor Institute (BTI) at Children's National, explores the developmental origins of childhood cancer, focusing on the molecular and cellular mechanisms that drive tumor initiation and progression. We develop and apply innovative research models and experimental systems to investigate how healthy cells are transformed into cancer cells and how tumor cells hijack developmental signaling pathways to establish and sustain disease. Ultimately, we aim to leverage these insights to inform preventive strategies and develop new therapeutic approaches.
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Lab Focus Areas
Cancer biology
Tumor immunology
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Contact
Elena Vasileva, PhD Principal Investigator evasileva@childrensnational.org
- External Website
Featured Publications
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Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm
Vasileva E, Arata C, Luo Y, Burgos R, Crump JG, Amatruda JF. PMID: 39554045 Cell Reports 29:2024.10.27.620438 2024 -
Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth
Vasileva E, Warren M, Triche TJ, Amatruda JF. PMID: 35285802 Elife. 14:11:e69734 2022